With the increasing competition in pharmaceutical and nutraceutical industry, these pharmaceutical companies put their best abilities to provide the very best treatment solution for the variety of ailments. In some cases, active pharmaceutical ingredients are used directly without going through any improvement processes. It completely depends upon the type of medicine or drug. After the medicine advancement stage using the best option APIs, these medicines are ready to be delivered on the market to provide best answer to treat many types of ailments.The incidence rate of AF reduced from 9.6 to 7.2 per 1,000 person-years after RAS blockers use. The modified HRs had been 0.80, 0.64, and 0.77 for pure ACEIs users, pure ARBs users, and mixed users, respectively. Among the RAS blockers users, 23.5 percent used RAS blockers for 28-365 times, and 76. The incidence prices of AF were 9.6, 8.8, and 6.8 per 1,000 person-years among patients who used RAS blockers significantly less than 28, 28 to 365, and more than 365 times, respectively. The occurrence of new-onset AF was considerably different between nonusers and those who utilized RAS blockers for 28-365 times along with those who used RAS blockers for >365 times .Table 2: Dose relation analysis for new-onset AF.Full size tableAge, CHADS2 score, CHA2DS2VASc score and treatment outcomeIn subgroup analyses, there was a common RAS blockers protective impact across gender categories .