23andMe’s a lot more than 60,000 customers are invited frequently to participate in a range of studies; eligible and consenting clients will be invited to join this study during 2011. The project described is supported by Award Quantity 1R43HG005807-01 from the National Human Genome Research Institute. This content is solely the responsibility of the authors and will not necessarily represent the official views of the National Human Genome Analysis Institute or the National Institutes of Wellness.. 23andMe project is aimed at validating highly scalable pharmacogenomics research Goal is highly scalable pharmacogenomics research23andMe has launched a project funded by the National Institutes of Wellness which is targeted at validating 23andMe’s highly-scalable system for pharmacogenomics study.Cortical demyelination occurring close to the onset of multiple sclerosis differs substantially from that observed in chronic multiple sclerosis. These findings usually do not support a primary neurodegenerative procedure during early-stage multiple sclerosis. Variations between cortical demyelination in early multiple sclerosis and in long-standing, progressive multiple sclerosis, where inflammatory cortical demyelination is normally not observed, may relate to effective clearance of cortical inflammation.38,39 Regarding a potential mechanism of disease progression, we speculate that myelin-laden macrophages may leave the cortex, enter the cerebrospinal liquid , gain access to deep cervical lymph nodes to market epitope spreading,40 and therefore propagate the disease process .