The recent rise of neonatal abstinence syndrome resulted in efforts in lots of hospital systems to boost hospital care being sent to infants with the syndrome, said business lead investigator Dr. Stephen Patrick, assistant professor of pediatrics and health plan at Vanderbilt University College of Medicine. Our findings suggest that these improvements need to extend beyond the original birth hospitalization to make sure a safe discharge house, he stated in a Vanderbilt news release.Study Design Females were randomly assigned to receive oral tamoxifen in a dose of 20 mg daily, tamoxifen plus ovarian suppression, or oral exemestane at a dose of 25 mg daily plus ovarian suppression. Treatment was for 5 years from the time of randomization, based on the scholarly study protocol, available at NEJM.org. Ovarian suppression was attained by choice of triptorelin at a dose of 3.75 mg administered by means of intramuscular injection every 28 days, bilateral oophorectomy, or bilateral ovarian irradiation. Patients receiving triptorelin could opt to undergo oophorectomy or irradiation subsequently.