The symptoms and specifically the severe forms are completely preventable.. Acute mountain sickness Most life-threatening altitude sickness is due to ascending with recognisable symptoms. Here is how to advise the intending high altitude traveller. Travellers of most ages are more and more accessing high altitude areas. It is important that general practitioners can easily advise their patients on minimising problems associated with high altitude. One particular problem is severe mountain sickness , which might range in display from mild to serious symptoms and is in charge of numerous deaths each year.RT-PCR analyses revealed that in both cells, just the transcript for full-length MRTF-A [GenBank: Abdominal037859.2] was expressed; transcripts for other MRTF-A isoforms [NCBI Reference Sequence: XM_005261691.1] and MKL1 transcript variant X2 [NCBI Reference Sequence: XM_005261692.1] weren’t expressed . These results suggest that MAL fl may be the main MRTF-A subtype in both cells. We verified that exogenously expressed mouse MRTF-A in HAoECs was also localized in the nucleus .Number 3: Properties of MRTF-A/B in HAoECs and HaCaT cells. HAoECs were cultured in HEC-C1 medium. HaCaT cells had been stained with anti-MRTF-A antibody or anti-MRTF-B antibody , phalloidine-Alexa 488 , and Hoechst 33258 .