These penetrated into the top dermis, and there have been areas of fibrosis containing melanophages .. A dark lesion with a predominant globular pattern Melanomas with a predominantly nested pattern create a predominantly globular design and may lack a definite pigment network on dermoscopy. Case presentation Over an eight-month period, a 74-year-old woman developed an enlarging dark lesion on the medial facet of her left foot .Dermoscopy revealed an asymmetrical lesion with an irregular border. The globules had been separated by irregular pale patches containing several dark pigment dots. There was no well-produced pigment network.A total of 15 patients did not obtain plasma exchange or infusion for the whole duration of the study. One individual received five sessions of plasma infusion or exchange without an interruption in eculizumab treatment, and 1 received plasma exchange or infusion after discontinuation of eculizumab and withdrawal from the study because of a protocol violation. Renal Outcomes After discontinuation of plasma exchange or initiation and infusion of eculizumab treatment, there were continuous, time-dependent increases in the estimated GFR from baseline to week 26 . This improvement was maintained at week 60 .