Sleep is usually that immune response, induced by the cytokine interleukin-2 produced in response to the endotoxins. But in order for the full immune response to occur, the entire sleep routine ordered by OUR MOTHER EARTH must be completed. This sleep routine begins with the creation of the sleep inducing hormone, melatonin. Production of melatonin starts in response to coming darkness, and it continues in to the wee hours of the entire night when production of another hormone, prolactin, kicks in. These two hormones promote white cells, known as macrophages and leukocytes, that thin out the herd of gut bacteria, restoring an optimal stability between us and them.Bar graph of proliferated OT-I Tcells in spleen of chow or WTD-fed ldlr mice. Representive CFSE dilution peaks of the OT-I Tcell population.Full size imageBatf3-dependent DCs are efficiently depleted in atherosclerotic batf3 mice were lethally irradiated and received bone marrow from CD45.1 mice. Without induction of atherosclerosis, dendritic cells in the aortas of the transplanted mice were very scarce , and they were completely ablated 4 days after irradiation treatment . In addition, we could show by flow cytometry that 6 weeks after irradiation, only 1.3 percent of immune cells in the vessel wall are CD45.2 positive , instead they were almost exclusively CD45.1 positive, demonstrating effective reconstitution of the resident immune cells in the vessel wall by donor cells .