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Sections of allelic imbalance on chromosome 3p were the just ubiquitous abnormalities . Taken together with the corresponding decreased array transmission intensities on chromosome 3p , this indicated lack of heterozygosity through one deletion occasions in these 3p sections encoding VHL and the histone H3K36 methyltransferase SETD2. No tumor regions shared identical allelic-imbalance profiles, and heterogeneity of allelic imbalance within metastases, which is most likely driven by aneuploidy, shows that chromosomal aberrations contribute to genetic intratumor heterogeneity. Intratumor Genetic Heterogeneity and Convergent Tumor Evolution A comparison of genes which were mutated in this tumor with genes recurrently mutated in clear-cell carcinoma4,22 identified VHL, KDM5C, SETD2, and MTOR .